Objective The value difference between 64 slice and 128 slice spiral coronary CTA in the evaluation of coronary stent restenosis was analyzed. Methods The coronary artery stenting in 50 patients from January 2014 to January 2016, divided into 64 slice coronary CTA examination group and 128 slice coronary CTA group; coronary angiography detection is the gold standard of diagnosis, compared with two groups of scan image quality, diagnostic efficacy between the two groups. Results 128 slice coronary CTA image quality score higher than 64 slice coronary CTA scan, and the difference is statistical significance (P<0.05). 128 slice coronary CTA examination were positive in 12 cases, 13 cases were negative, 64 slice coronary CTA examination were positive in 21 cases, 4 cases were negative; 128 slice spiral CTA in the diagnosis of coronary artery. Specificity, positive and negative predictive value and diagnostic accuracy were significantly higher than that of diagnosis of 64 slice spiral CTA coronary artery, The image quality of the 128 slice spiral coronary CTA is better than that of the 64 slice spiral coronary CTA. Conclusion The diagnostic efficacy of 128 slice spiral coronary CTA is significantly higher than that of 64 slice spiral coronary CTA