Objective To compare the enhancement degree of pancreas of CT enhancement scanning with different triggering position and threshold, in order to obtain the best image quality, and to compare the difference of enhancement degree in various parts of pancreas. Methods A total of 80 patients who underwent epigastric CT enhancement were prospectively selected and randomly divided into group Ⅰ and Ⅱ, in which thoracic aorta and left atrium were located as the region of interest (ROI) of triggering position. Patients in each group were divided into A, B, C and D subgroups. 90, 120, 150 and 180Hu were taken as the monitoring threshold tracking triggers, respectively. Difference between average CT value of head, body and tail of pancreas and CT value of duodenum were compared. Results The difference of CT value between pancreas and duodenum in subgroup ⅠA, ⅠB, ⅠC and ⅠD was (23.28±9.52)HU, (35.86±12.50)HU, (23.50±6.44)HU and (18.40±6.28)HU, respectively. Significant difference was found between ⅠB and the other subgroups in group Ⅰ(all P<0.05). The difference in subgroup ⅡA, ⅡB, ⅡC and ⅡD was (21.11±5.53)HU, (25.94±6.60)HU, (34.65±8.52)HU and (26.44±7.13)HU, respectively. Significant difference was found between ⅡC and the other subgroups in group Ⅱ(all P<0.05). No significant existed between ⅠB and ⅡC subgroup(P=0.803). No significant diference was found among the CT value of head, body and tail of pancreas in every subgroups(all P>0.05). Conclusion Locating at thoracic aorta as the ROI, and taking 120HU as the monitor threshold or locating at left atrium as the ROI, and taking 150HU as the monitor threshold enables the best pancreatic image quality in epigastric CT enhancement. No significant difference of enhancement degree existed in various parts of pancreas.