Objective Detailed nursing intervention was performed on patients with enhanced CT scan, and psychological status of patients before examination was observed. Methods A total of 100 patients with enhanced CT scan were selected and randomly divided into observation group and control group. The observation group was given detailed nursing intervention mode, while the control group was given conventional nursing mode. The psychological status, the time needed for scanning, the image quality, the side effects, and the evaluation of the nursing work were observed in the two groups before the examination. Results The psychological state of patients in the observation group was more stable, the examination time was shorter, the side effects were less, and the patients' evaluation of nursing work was higher, the difference was statistically significant (P<0.05). Conclusion Application details of nursing intervention model before enhanced CT scan, patients can has more healthy attitude to face inspection, reduce the side effects in the examination, and promote the harmonious development of nurse patient relationship, it is worth in clinical work.