Objective To evaluate CT clinical manifestations in the diagnosis of hepatic veno-occlusive disease. Methods The clinical data of 80 cases of hepatic veno-occlusive disease patients who were treated in Sheyang County People's Hospital from May 2008 to May 2014 were statistically analyzed. Results Among the 80 cases of patients, unenhanced 64 cases were with plaque uneven density decreases, 16 cases diffuse liver parenchyma lower, accounting for 80.0%, 20.0% of the total, respectively; 28 cases were enhanced hepatic arterial phase and patches reinforcement change, 16 cases small patchy enhancement occurs in the liver, 36 cases did not change significantly enhanced, 35.0%, 20.0%, 45.0% of the total, respectively; 16 cases were with portal vein hepatic vein or the lack of a clear display not shown, 4 cases had thin like changes appear in the right hepatic vein, 20.0%, 5.0% of the total, respectively; Delayed 3-5min 70 cases were equilibrium phase and delayed phase spiral CT scans in show whole liver patchy low density change at least one liver segment, 10 cases substantially more uniform, 87.5%, 12.5% of the total, respectively. Delay>10min display 34 cases were still scattered in small patchy low-density areas, 42.5% of the total. Conclusion Enhanced CT scan has high clinical diagnostic value in the diagnosis of hepatic veno-occlusive disease.