Objective To investigate CT imaging signs and value in patients with lacrimal duct obstruction diseases. Methods 32 patients (64 eyes) who were treated in the hospital because of epiphora were selected as the research objects. All the patients underwent CT angiography of lacrimal duct. Results Among the 32 cases (64 eyes), 21 eyes were normal (32.81%) and 43 eyes with obstructive disease of the lacrimal duct (67.19%), including 6.98% of general lacrimal duct obstruction, 11.63% of lacrimal canaliculus obstruction and 81.39% of nasal inner tube obstruction. Among the 35 eyes with nasal inner tube obstruction, there were 2.86% with recurrent dacryocystitis, 88.57% with chronic dacryocystitis and 8.57% with dacryocyst cyst. CT sagittal images showed that there were 42.86% of the nasal obstruction in the upper tube, 40.0% in middle section nd 17.14% in the hypomere of eyes. 21 eyes were normal. After injection of contrast media, the lacrimal canaliculus and lacrimal sac were developed and there was contrast agent in the nasal cavity. 5 eyes with lacrimal canaliculus obstruction manifested as imaging interruption in lower lacrimal canaliculus and there was no contrast agent in lacrimal sac and nasal cavity. The general lacrimal ducts of 3 eyes indicated development in conjunctival sac and lacrimal canaliculus and there was no development in lacrimal duct and nasal inner tube. 35 eyes with nasal inner tube obstruction manifested as development in lacrimal canaliculus and lacrimal sac and imaging interruption in nasal inner tube. The lacrimal sac approximate areas of oblique sagittal, axial and oblique coronal chronic dacryocystitis were significantly higher than those of normal eyes and the difference was significant (P < 0.05). Conclusion CT dacryocystography can be used as one of the important imaging methods for clinical diagnosis of lacrimal duct obstruction diseases.