bjective To compare the application value of color Doppler ultrasound, MRI and the combination of the two in the clinical diagnosis of breast neoplasms. Methods 63 cases of patients with breast neoplasms diagnosed by operation and pathology and admitted into the hospital during April 2012 to April 2015 were selected as the research objects. The color Doppler ultrasound examination and MRI examination were performed, respectively. The diagnostic accuracy was compared. Results The accuracy rate of combined diagnosis was the highest which was 95.2% while of color Doppler ultrasound and MRI were 82.5% and 84.1%, respectively, and the difference between color Doppler and MRI was not statistically significant (χ2 =0.057, P=0.811>0.05). The comparison between color Doppler ultrasound and the combined diagnosis was statistically significant (χ2 =5.143, P=0.023<0.05). The comparison between MRI and combined diagnosis was statistically significant (χ2 =4.203, P=0.040<0.05), which showed that combined diagnosis had obvious advantages. The diagnostic accuracy rate was greatly improved. Conclusion The application of color Doppler ultrasound and MRI in the clinical diagnosis of breast cancer is of great value, but the combination of the two can correct each other and substantially increase the diagnostic accuracy, which provides a more accurate basis for clinical treatment.