Objective This Paper is to investigate clinical value on 16-sliced computed tomography (CT) and 1.5 T magnetic resonance cholangiopancreatography used in clinical grouping diagnosis on gallbladder stone combined with choledocholithiasis. Methods Eighty patients with gallbladder stone combined with cholangiopancreatography were selected as research candidates, patients undergoing 16-slice CT examination (80 patients) were divided into the control group, patients undergoing 1.5 T magnetic resonance cholangiopancreatography (80 patients) were selected into the research group, and surgical results serve as standard. Clinical diagnosis details of two groups of patients were compared. Results Eighty patients were surgically confirmed to suffer from calculus, 60 patients in the control group were diagnosed to suffer from such disease, and the value of such disease in the research group was 75, the accuracy rate on patients in the research group was higher than that of patients in the control group, the inter-group difference was significantly (P<0.05). xx patients suffering from the calculus with the diameter below 0.8cm were subject to choledochectasia, and that value in the control group was xx, the accuracy rate on patients in the research group was higher than that of patients in the control group, the inter-group difference was significantly (P<0.05). Conclusions The accuracy of 1.5 T magnetic resonance cholangiopancreatography is higher than that of 16-slice CT in clinical diagnosis of gallbladder stone combined with choledocholithiasis, and especially 1.5 T magnetic resonance cholangiopancreatography delivers obvious advantages in diagnosing the calculus free from choledochectasia with relative diameter less than 0.8cm.