Objective To explore the use of colon CT imaging in the diagnosis of colon polyps radiologists to assess differences. Methods Collection in April 2013 to March 2015 period in our hospital between examination was highly suspected as colon polyps in 120 cases of patients with colon CT image data, by four different levels of radiologists in use and do not use the auxiliary diagnostic tool for reading, fiber colonoscopy as gold standard, at different levels of doctors in different cases of colon polyps detection sensitivity, specificity, accuracy, positive predictive value and negative predictive value. Results At the physician in the diagnosis of colon polyps detection under the condition of same comparison difference has no obvious statistical significance (P>0.05); Different levels of physicians in without auxiliary diagnostic tool for colon polyps detected situation is difference have significant statistical significance (P<0.05); Different levels of physicians in the use of auxiliary diagnostic tools of colon polyps detection under the condition of comparison difference has no obvious statistical significance (P>0.05); High qualification levels of physicians in the use of auxiliary diagnostic tools, relative improve detection rate of colon polyps, but with the auxiliary diagnostic tool is not used there was no obvious difference detection than statistical significance (P>0.05). Conclusion CT imaging in the diagnosis of colon colon polyps assessment greatly depends on the level of seniority of radiologists, by adopting CAD auxiliary diagnosis can reduce or eliminate differences.