Objective Aided design of atlas pedicle screw placement scheme using Mimics software and rapid prototyping technology, assisted reduction and internal fixation operation in the treatment of posterior dislocation of atlas axis fracture line. Methods CT scan was performed to collect data on adult atlantoaxial specimens, will generate the data into Mimics software for three-dimensional reconstruction of atlantoaxial specimens, and atlantoaxial pedicle screw placement for the best axis in the three-dimensional reconstruction and the related data were measured using the software function; to reconstruct 3D image as a template to the posterior arch of atlas and spinous process of anatomic landmark by the snap design guide screw, the vertebral reconstruction model and 3D guide to STL image format into 3D printer, making the vertebral model and guide. The application of pedicle screw guide medical records were analyzed and compared with the traditional pedicle screw surgery with medical records data. Results Successfully established with high similarity of the atlantoaxial specimens of 3D image and physical model, and successfully fabricated screw guide, successfully performed on 50patients with atlantoaxial pedicle screw in screw guiding device, compared with traditional pedicle screw placement operation, the study group accepted rate of 100% significantly higher than the control group in the nailing acceptable rate of 87.5%, (P<0.05). Patients with higher JOA score (P<0.05). Conclusion Aided design of atlas pedicle screw placement scheme can even improve the accuracy of screw placement using Mimics software and rapid prototyping technology, can improve the therapeutic effect.