Objective To observe the efficacy of GE1.5 T Magnetic Resonance Brain MRA Imaging applied for clinical diagnosis of cerebrovascular disease and to evaluate clinical application value and short-term and long-term prognosis. Methods Four hundred and eighty patients with cerebrovascular disease admitted by the Department of Cardiovascular Internal Medicine of the Hospital were selected, and they were defined into the observation group (240 patients, GE1.5T Magnetic Resonance Brain MRA Imaging diagnosis) and the control group (240 cases, conventional MRI diagnosis) according to different diagnostic methods, results of clinical diagnosis of two groups of patients were compared, and short-term and long-term prognosis was analyzed. Results The total positive rate of disease types of patients in the observation group and the control group hit 100% and 80.4% respectively, the two-by-two data analysis satisfied (χ2 =52.10, P＜0.05). Abnormal changes in common vascular diseases and forms of blood vessels were obviously shown in MRA imaging manifestations of 240 patients. The follow-up action was made in during the period from one month to one year after diagnosis, the proportions of aphasia, hemiplegia and hemiplegia plus aphasia of patients in the observation group occupied 5.4%, 10.4% and 3.8% respectively, and those indexes of patients in the control group were 10.9%, 17.1% and 9.3% respectively. The intergroup data was compared, and the differences were statistically significant (χ2 =4.41, 4.12 and 5.69, P＜0.05). Conclusion GE1.5T MRI brain MRA is provided with advantages including noninvasive, effective, rapid, accurate and simple operations, the positive rate of cerebrovascular disease in clinical diagnosis was high, and the development was clear, providing accurate judgment basis for therapy program and prognosis improvement in clinical science.