Objective This paper is to investigate clinical diagnosis value of low dose of 64–slice spiral CT scanning and contrast-enhanced ultrasonically in the diagnosis of Small hepatic carcinoma. Methods The years of research extended from December, 2012 to December, 2014, and research subjects were 38 patients admitted by the outpatient clinic and the inpatient department were indicated to suffer from liver space-occupying lesions via ultrasonic examination, 19 patients in the control group were subject to low dose of 64-slice spiral CT multi-phase scanning, and 19 patients in the experiment group were subject to contrast-enhanced ultrasonically. Diagnosis results of patients in two groups were compared on the basis of clinically pathological diagnosis. Results The sensitivity (100.00%) and accuracy (94.74%) of CT examination were higher than those of ultrasound examination (96.63% and 94.44%), but the specificity (98.24%) of CT examination was lower than that of ultrasound examination (100.00%).The intergroup comparison satisfied P>0.05,and there is no significant difference. Medium and small unicellular carcinoma lesions in CT examination mainly manifested enhanced sign of typical "Fast-out and Fast-in" with misdiagnosis rate ar 5.26%. Conclusion Diagnosis of 64 slice spiral CT scan combined with double arterial phase of contrast-enhanced ultrasound on SHCC has higher accuracy, sensitivity and specificity, which can lack of blood supply, not the typical SHCC unicellular carcinoma by accurate diagnosis, to recommend the preferred option for use in clinical diagnosis.