Objective To analysis the micro-sized particles and strengthening distribution characteristics of different lung masses on enhanced CT scan, and to explore theirs diagnostic value. Methods 68 patients with lung mass confirmed by histopathological examination and clinical follow-up were examined with enhancement CT. Then all lung masses were divided into three groups :malignant, benign, and active inflammation, Analysised on the micro-sized particles and strengthening distribution characteristics of each groups, examined the association between the nature of lung mass and the microstructure characteristics using chi-square test, compared each of the two groups. Results The micro-sized particles were moderate Associated with the nature of lung masses (fisher value=51.119, P<0.001), Contingency Coefficient was 0.649, malignant masses were mainly micro particle type high proportion, benign masses were mainly large particle type high proportion, inflammatory masses were mainly large particle type and mixed type high proportion .The improved distribution type were moderate associated with the nature of lung masses (fisher value = 42.662, P<0.001), Contingency Coefficient was 0.605, malignant masses were mainly edge reinforcement high proportion, the benign masses and inflammation masses were mainly the central reinforcement high proportion. Conclusion The micro-sized particles and strengthening distribution characteristics of the lung masses with different nature may reflect the characteristics of the pathological changes of different masses, it is very helpful to diagnose and differential diagnoses of lung masses.