Objective To discuss the CT manifestation of pulmonary fungal infection, and the differential diagnosis of lung cancer and tuberculosis. Methods Collecting 36 cases confirmed by pathology, CT examination data of 64 layer of pulmonary fungal infection, at the same time random collection period lung cancer and tuberculosis all CT data of 30 patients as control group. Analyzing the imaging data of the team, the control group, and compare the two respectively CT signs Presence of Statistical differences. Results 36 cases of pulmonary fungal infection in patients, mostly in the stove double lung disease 26 cases, patch, nodular type 15 cases, tumor type 13 cases, solid variant 8 cases; The Mainly signs include shallow lobulation,deep lobulated, the air-filled bronchi, long burr, short burr, cavitation and halo sign; In lung cancer group deep lobulated, air-filled bronchi, abnormal bronchial beam, long burr, halo sign appear frequency relatively less research obviously, and sag,cavitation,mediastinal lymph nodes enlargement, more obvious than the team between statistical differences (P<0.05); TB group shallow lobulation sign,deep lobulated sign, air-filled bronchi, abnormal bronchial beam, short burr,long burr, and halo sign appear frequency relatively less research group obviously, and satellite stove, calcification, lymph nodes are enlarged, more obvious than team between statistical differences (P<0.05). Enhanced scan, the CT added value of pulmonary fungal infection was statistical difference with the control group (t1=5.62, P<0.05 t2=5.71, P<0.05). Conclusion Pulmonary fungal infection imaging findings with diversity,"crescent sign" appears typical aspergillus ball can clear the diagnosis of pulmonary aspergillosis, if appear ground glass shadow and "halo sign" is the expression of the fungal infection lesions are more characteristic; In addition, the double lung multiple lesions, signs, and change quickly, suggest possible fungal infection.