Objective To investigate the effect of Shugan Treatment of Nonalcoholic fatty liver and liver CT imaging efficacy differences before and after treatment. Methods 60 cases diagnosed as non-alcoholic fatty liver disease were randomly assigned to a treatment group and a control group of 30 patients, The control group received diet and adequate exercise to adjust for treatment, the treatment group took Shugan Xiaozhi Fang on this basis, Analysied and comparison of the two groups CT, clinical and biochemical indicators of change in three months. Results The treatment group in the total efficiency of 93.33%, 86.67% in the control group, the difference was statistically significant (P <0.05); Compared with the control group, the ALT, AST, TC and TG and other indicators of liver function of treatment group were improved, and the difference was statistically significant (P <0.05); compared with before treatment, the treatment of liver and liver CT value / spleen CT ratio were increased, the difference was statistically significant (P <0.05); After treatment compared with the control group, the treatment of liver and liver CT value / spleen CT ratio were increased, the difference was statistically significant (P <0.05). Conclusion Shugan Xiaozhi Fang treat non-alcoholic fatty liver disease significantly, CT quantitative techniques to assess medical treatment of nonalcoholic fatty liver disease method is safe, accurate.