Objective To evaluate the diagnostic value of CT imaging of the small intestine (CTE) for Crohn's disease. Methods 25 patients with pathologically confirmed and CTE examination were analyzed retrospectively. Two doctors without knowing pathological situations were blinded to analyze the performance of its CTE. Results Of two doctors diagnose Crohn's disease by CTE accuracy were 90.60% and 87.40%, CTE can clearly show lesions and bowel changes, in 25 patients, 12 cases involving only the small intestine (48%), which simple terminal ileum or ileocecal involvement in 5 cases, small intestine and colon simultaneously involved in 10 cases (40%), only 3 cases involving the colon (12%). All 25 cases of Crohn's disease CTE showed thickening of the bowel, intestinal stenosis, intestinal enhanced scan showed a layer-like or overall enhancement, bowel axial like to see a "target" sign, increased mesenteric vessels. 18 cases (72%) see "comblike" symptoms. 15 cases (60%) see the mesenteric lymph node enlargement, clear edge. 2 cases (8%) seen in the fistula formation, one case (4%) incomplete small bowel obstruction. Conclusion CTE examination can multi-faceted display the abnormalities of intestinal wall, intestine, mesenteric, intra-abdominal lymph node and corresponding complications as a primary screening method can diagnose Crohn's disease.