Objective To evaluate the diagnostic performance of 18F-FDG PET/CT and contrast-enhanced multi-slice CT for pancreatic cancer. Methods Document retrieval was conducted on PubMed, EMbase, The Cochrane Library, Web of Science, CBM, WanFang Data and CNKI to retrieve the diagnostic studies about PET/CT and contrastenhanced multi-slice CT in the diagnosis of pancreatic cancer, the last retrieve time was March 2015. Two reviewers independently screened literature according to inclusion and exclusion criteria, extracted data, and assessed methodological quality of the included studies. Meta-analysis was then conducted using Meta-Disc 1.4 software. Results A total of eleven studies involving 509 patients met the eligible criteria. With the comparison of histopathology results (surgery or biopsy) or serial follow ups, which were considered as gold standard, the pooled sensitivity (SEN) and specificity (SPE), the area under (AUC) of the summary receiver-operating characteristic curve (SROC) were 0.93 [95%CI (0.89, 0.95)], 0.76[95%CI (0.67, 0.83)], 0.9149 and 0.80 [95%CI (0.75, 0.84)], 0.66 [95%CI (0.57, 0.75)], 0.8159 for PET/CT versus contrast-enhanced CT in diagnosing pancreatic cancer, respectively; the pooled SEN and SPE, the AUC value were 0.98 [95%CI (0.94, 0.99)], 0.90 [95%CI (0.81, 0.96)], 0.9873 for combining above two methods, respectively. Conclusion 18F-FDG PET/CT had a high sensitivity than contrast-enhanced multi-slice CT in diagnosing pancreatic cancer, the specificity was not significant difference, but both methods combination can further improve the diagnostic accuracy.