Objective To study the clinical value of multi-slice spiral CT angiography (MSCTA) in the diagnosis of intracranial aneurysms. Methods 40 patients with intracranial aneurysms which were confirmed by operation or digital subtraction angiography (DSA) during February 2012 to August 2015 were selected as the research objects. All patients underwent MSCTA examination and their performances (the posotion, form and size, etc. were observed and compared with the results of DSA. Results MSCTA detected cerebral aneurysm in 38 cases (95.0%) and DSA detected 39 cases (97.5%). There was no statistically significant differences in the comparison of diagnostic sensitivity between the two groups (χ2 =0.346, P>0.05). The maximum diameters of cerebral aneurysm and aneurysmal neck detected by MSCTA were (9.98±2.54) mm and (4.29±1.45) mm. Compared with (10.07±2.30) mm and (4.32±1.32) mm detected by DSA, the difference was statistically significant (P>0.05). There was no statistically significant differences in the diagnostic results of the location of intracranial aneurysms diagnosed by MSCTA and DSA (P>0.05). Conclusion The sensitivity of MSCTA in the diagnosis of intracranial aneurysms is highly. It is similar to DSA and is non-invasive and easy to operate, which is worthy of clinical promotion.