Objective To observe and evaluate the clinical effect of traditional Chinese medicine nursing intervention in the treatment of ulcerative colitis (UC) with Kuijie enema and intestine. Methods A total of 138 patients with ulcerative colitis treated in the hospital between March 2015 and February 2018 were selected and treated by self-made pudding enema and intestine, and randomized controlled trials (RCT) were divided into two groups. Control group 69 Cases were given routine care. 69 patients in the observation group were given comprehensive nursing interventions on the basis of the control group, and the clinical effects of the two groups were compared. Results Before the nursing intervention, there was no significant difference in clinical symptom scores between the two groups (t=0.1674, P>0.05). After the nursing intervention, the clinical symptom scores of the observation group and the control group were significantly reduced (t=15.3076, 13.0539, P<0.05). The scores of patients in the observation group were significantly lower than those in the control group (t=11.0285, P<0.05). The total effective rate was 98.55% in the observation group was significantly higher than that in the control group (75.36%) (χ2 =16.3556, P=0.0000). The satisfaction rate of observation in the observation group was 97.73% was significantly higher than 79.55% in the control group (χ2 =12.6407, P=0.0000). Conclusion Self-made pudding enema and intestine evacuation therapy for UC and traditional Chinese medicine nursing intervention can effectively improve the clinical cure rate and nursing satisfaction, significantly relieve the clinical symptoms of patients, and it is worthy of clinical application.