Objective To observe and evaluate the clinical effect of Leonurus injection in postpartum systolic and hemostasis. Methods A total of 160 natural vaginal delivery mothers were selected from July 2015 to June 2017 at ShanweiYihui Fund Hospital (Shanwei Second People’s Hospital). The Randomized Controlled Trials (RCT) were divided into two groups. Eighty patients in the group were treated with vaginal delivery of oxytocin after delivery of the placenta; 80 patients in the observation group were treated with Motherwort injection on the basis of the control group, and the bleeding volume and clinical efficacy of the two groups were observed. Results The amount of bleeding at 2h and 24h postpartum in the observation group was significantly lower than that in the control group (t=34.8643, 29.5728, P<0.05, respectively), the incidence of postpartum hemorrhage in the observation group was significantly lower than that in the control group (11.25%) (χ2 =4.7834, P<0.05). The height of the uterus at the 2nd, 4th, and 6th days after maternal use was gradually shortened in the two groups, while the height of the uterine fundus in the observation group was 2d, 4d, and 6d after the administration. Significantly shorter than the control group (t=3.1257, 3.9013, 4.0376, respectively, P<0.05). Conclusion The vaginal delivery of natural maternal motherwort injection combined with oxytocin can effectively prevent postpartum hemorrhage, less bleeding, low bleeding rate, increase the intensity of contractions, and has an ideal effect on maternal postpartum uterine recovery. It is worthy of clinical application.