Objective To analyze and evaluate the clinical value of ultrasound in the diagnosis of diabetic patients with carotid and lower extremity arteriosclerosis. Methods In our hospital from October 2014 to February 2017 100 cases of diabetic patients compared with 100 cases of non diabetic patients as the research subject. The set of A group and B group were given color Doppler ultrasound examination. The detection results were compared between the two groups of carotid and lower extremity arteries. Results In A group, the carotid IMT (carotid intima-media thickness) incidence rate (86%),(62%) the detection rate of plaques and stenosis rate (36%) was higher than that of B group was 23%, 16% and 14%, the difference was significant. There was statistical significance (P<0.05) the incidence of lower extremity arteries in. A group IMT (82%),(80%) the detection rate of plaques and stenosis rate (34%) was higher than that of B group was 15%, 13% and 11%, compared with significant difference, with statistical significance (P<0.05). A In the group, endometrial examination results: near IMT bifurcation sites of uneven thickening, 62 cases, the incidence was 62%, lower extremity arterial intimal rough uneven thickening in 80 cases, the incidence rate was 80.00%. Conclusion For patients with diabetes by ultrasonography, can better diagnose lesions of carotid and lower extremity arteries the incidence of atherosclerosis, early detection, effective treatment of the patients, the diagnostic value was high, the security can be extended.