Objective To investigate and analyze the predictive value of epicardial adipose tissue thickness in patients with coronary heart disease. Methods 152 cases of August 2015 -2017 year in July were treated in the Department of Cardiology in our hospital patients as the research object, according to the prevalence of patients with group A, group B, group A patients of coronary heart disease, 76 cases of group B non coronary heart disease patients, 76 cases. All patients were measured blood samples, coronary angiography, ultrasonography, and evaluation of the two groups were related to index level. Results Two groups of patients with a left ventricular ejection fraction, C reactive protein, high density lipoprotein cholesterol, interleukin 10 the level of triglyceride level difference comparison was not statistically significant (P>0.05). The level of the group of patients with epicardial adipose tissue thickness, total cholesterol, low density lipoprotein cholesterol, coronary artery The degree of vein stenosis were higher than group B patients, compared the difference was statistically significant (P<0.05). Positive correlation with epicardial adipose tissue thickness and the severity of coronary artery disease. Conclusion In the prediction of coronary heart disease, epicardial adipose tissue thickness value is very high, can predict the severity of patients. The method is simple and noninvasive, the clinical application is very strong.