Objective To analyze the effect of ginkgo dipyidamolum injection in the treatment of acute coronary syndrome (ACS), and explore its influence on lipid metabolism and platelet aggregation. Methods A total of 90 patients with acute coronary syndrome in our hospital were were taken as the clinical research objects, and they were randomly divided into A group (45 cases) and B group (45 cases). Both groups were treated with conventional western medicine, besides, the B group was given additional ginkgo dipyidamolum injection. The improvement of angina pectoris, platelet aggregation rates, lipid levels and adverse reactions in the two groups were compared. Results The effective rate of angina pectoris improvement in the B group was 95.56% which was higher than that in the A group 80.00%, and their difference was statistically significant(P<0.05). After treatment,the lipid level in the B group was obviously improved, and it was significantly lower than that in the A group(P<0.05), the platelet aggregation rate in the B group was decreased, and it was significantly lower than that in the A group (P<0.05). The adverse reaction rates in the B and A group were respectively 4.44% and 2.22%, the difference between the two groups was not statistically significant(P>0.05). Conclusion Ginkgo dipyidamolum injection can not only relieve angina symptoms in ACS patients, but also improve platelet aggregation rate and lipid metabolism. Thus, it is worthy of application in clinic.