Objective To compare the curative effects and complications of different pastes combined with gutta percha point in one-time filling root canal treatment. Methods From Apr. 2014 to Sep. 2016, a total of 136 patients (159 affected teeth) who accepted one-time filling root canal treatment in our hospital were taken as the clinical research objects. All the affected teeth were randomly divided into A group (53 cases) , B group (53 cases) and C group (53 cases), and treated by one-time root canal filling with gutta percha point plus cortisomol paste (group A), vitapex paste (group B) and zinc oxide eugenol paste (group C). The pain degrees 1 week after operation and 1 year follow-up curative effects in the three groups were compared. Results Patients with no or mild pain in A and B group were obviously more than those in C group, and their differences were statistically significant(P<0.05), patients with moderate pain in A group were obviously less than those in C group, and their difference was statistically significant(P<0.05), the total effective rates in A and B groups were respectively 98.1% and 96.2% which were remarkably higher than that in C group 84.9%, and their differences were statistically significant(P<0.05). After 1 year follow-up, there were 3 cases of spontaneous pain in A group and 11 cases of spontaneous pain in C group, and the difference between the two groups was statistically significant(P<0.05). Conclusion Gutta percha point plus cortisomol paste, vitapex paste and zinc oxide eugenol paste in one-time filling root canal treatment all have good effects, espically cortisomol paste plus gutta percha whose pain relief effect and long-term effect is better.