Objective To explore the physiological and psychological nursing in elderly patients in cardiology department, to provide data support for the effective nursing. Methods 120 elderly patients were selected as observation group from January 2014 to May 2015 in our hospital cardiology department, which physical and psychological nursing were proceed. In the same period, 100 cases were selected as control group for normal nursing, and the nursing effect of two groups were compared. Results Patients with myocardial infarction, sudden death, hypertensive crisis, malignant arrhythmia was significantly lower than that of control group, the differences were statistically significant (P<0.05), observation of hospitalization patients, hospitalization costs significantly lower than the control group, the differences were statistically significant (P<0.05), patients in the observation group on nursing quality satisfaction (100%) was significantly higher than the control group (88%), the difference was statistically significant (P<0.05). Conclusion The patients with psychological and physiological state analyzed and targeted intervention, can shorten the hospitalization time and improve the satisfaction.