Objective To study and observe the clinical pathways in the application of nursing care in patients with asthma. Methods Seventy - two patients with asthma were admitted to our hospital from May, 2011 to February, 2013 and divided into observation group and control group by random sampling. Nursing intervention was given to the clinical nursing pathways of the patients in the observation group, the routine nursing intervention was given to the control group, and the clinical nursing effect of the two groups was observed and compared. Results The clinical symptoms of the 32 patients in the observation group were significantly improved, with an average hospital stay of (10.2 ± 2.1) days. In the control group, the clinical symptoms were improved in 23 cases (15.3 ± 1.6) days. The nursing effect of the observation group was better than that of the control group, the difference between the two groups was statistically significant (P<0.05). The nursing satisfaction of the patients in the observation group was 97.22%, and the satisfaction degree of the control group was 77.78%. The nursing satisfaction of the observation group was significantly higher than that of the control group. There was significant difference between the two groups (P<0.05). Conclusion The clinical pathways of patients with asthma can improve the participation of patients and form active nursing model, which is worth popularizing.