Objective To explore the high risk factors of cardiac events in patients with cardiovascular interventional therapy and nursing intervention. Methods From January 2010 to December 2015, 109 cases of patients with cardiovascular interventional diagnosis and treatment were divided into high risk group and normal group according to whether there was myocardial infarction or re-infarction, heart failure and malignant arrhythmia before and after operation. A single factor regression analysis was used to collect the data from the two groups, and then more factors Logistic regression analysis was used. Results The 12 influencing factors were the risk factors of cardiac events during the cardiovascular interventional therapy. Age≥60 (RR=4.02), high blood lipid (RR=3.98), smoking history≥2 years (RR=4.36), combined hypertension (RR=5.4), complicated with diabetes (RR=7.61), history of angina pectoris (RR=5.34), history of myocardial infarction (RR=5.55), history of cerebrovascular accident (RR=4.21), history of heart failure (RR=4.19) were the high risk factor. Conclusion The high risk factors of cardiac events before and after cardiovascular interventional diagnosis and treatment are many and complex, appropriate symptomatic care measures are used to reduce the incidence of cardiac events.