Objective To study the effect of comprehensive nursing intervention on clinical efficacy and psychological status of patients with irritable bowel syndrome. Methods A total of 120 patients with irritable bowel syndrome in our hospital were selected as the clinical research objects, and they were randomly divided into control group and observation group. The control group was given traditional nursing, and the observation group was given comprehensive nursing intervention. The clinical efficacy and psychological status (anxiety, depression and etc.) in the two groups were compared after nursing. Results After treatment, the total effective rate in the observation group was higher than that in the control group, and their difference was statistically significant (P<0.05). After comprehensive nursing intervention, the scores of self-rating anxiety scale (SAS) and self-rating depressive scale (SDS) in the observation group were significantly lower than those in the control group, and their differences were statistically significant(P<0.05). Conclusion Comprehensive nursing intervention can not only effectively improve the clinical efficacy of patients with irritable bowel syndrome, but also alleviate patients' anxiety, depression and other adverse psychological status. Thus, it is worthy of clinical promotion