Objective To evaluate the clinical effect of Bobath therapy for pediatric brain injury syndrome. Methods 60 cases hospitalized with brain injury syndrome in our hospital from January 2014 to August 2016 were selected as the study object. According to the order of admission, they were randomly divided into experimental group and control group, and 30 cases in each group. The therapy of experiment group in children with brain nutrition drugs and Bobath treatment combined while only the brain nutrition drug was used in control group. Two groups were compared before and after treatment in patients with clinical efficacy and Gesell development diagnosis scale (Gesell developmental scales, GDS) score changes. Results The clinical efficacy of the children in the experimental group was significantly better than children in the control group, the difference was statistically significant (P<0.05). Children in the experimental group after treatment GDS score improved situation than children in the control group, the difference was statistically significant (P<0.05). Conclusion The brain nutrition drug combination Bobath therapy of brain injury syndrome has a significant treatment effect, and can improve children GDS score significantly, which should be popularized.