Objective To analyze the impact of coronary heart disease to severe and very severe COPD patients in acute exacerbation hospitalization, length of stay, mortality. Methods 227 COPD patients stage Ⅲ-Ⅳ clinical data was retrospective analyzed. They were divided into the coronary heart disease group (69 cases) and the control group (158 cases). Hospitalization length, frequency of exacerbations and mortality rates were analyzed and compared. Results There were 32 cases dead in two groups, 15 cases in the coronary heart disease group and 17 cases in the control group with statistically significant. The last hospitalization length was 16.1±11.5 days in the coronary heart disease group and (10.9± 7.1) days in the control group. The acute exacerbation hospitalization frequency is (6.5±5.23) in the coronary heart disease group and (3.9±5.7) in the control group in the last two years. The difference was statistically significant. Conclusion Coronary heart disease increases the duration of hospitalization, the frequency of exacerbations and mortality in patients with COPD patients.