Objective To investigate the relationship between resistin and metabolic index in obese children. Methods Fortyfive cases of simple obese children and 35 healthy children of similar age and gender (control group) were enrolled. Their fasting height, body mass, waist circumference(WC) and hip circumference were measured, and body mass index(BMI), waist to hip circumference ratio(WHR), waist circumference to height ratio(WHtR) were calculated in the early morning. The serum levels of insulin (FINS), sugar (FBG), cholesterol (TC), three acyl glycerin (TG), highdensity lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were detected at same time, which contributed to the calculation of homeostasis model assessment-Insulin resistance (IR=FINS×FBG/22.5). Serum resistin levels were measured by ELISA. Results Serun resistin level in obese group was 27.76(17.35, 53.23) ug·L-1, significantly higher than 21.53(15.85, 29.36) ug·L-1 of the healthy control, Z=-2.076, P=0.038. It was positively correlated with BMI, WC, WHR, WHtR and serum TG level, all P<0.05, and no correlated with IR. Conclusion Serun resistin level obviously increase in obese children, and it was closely related to obesity degree(especially abdominal obesity) and serum TG level.