Objective To investigate the clinical characteristics of cytomegalovirus(CMV) pneumonia in immunocompetent infants. Methods Analyze the clinical datas of 10 infants with CMV pneumonia was diagnosed by CMV-DNA quantitative detection in bronchoalveolar lavage fluid plus CMV-IgM detection by ELISA, and cases co-infection with other pathogens were excluded. Results Thirteen cases were recruited , 8 cases were male, 10 cases aged ranged from 1 to 3 months, 7 cases have a course more than two weeks on admission. All had cough; 76.9% cases had tachypnea; 61.5% cases had wheezing; 23% cases had cyanosis and 30.8% cases had fever 92.3% cases had rales. Some cases had liver function and audition damage. The lymphocytes were increased, CRP were normal in 84.6% cases. There was no child with jaundice, hepatosplenomegaly, rash or malnutrition. The chest Computed Tomography showing consolidation in 4 cases and interstitial lesions in 6 cases and mixed in 3 cases. Except one treated with immunoglobulin, 12 cases treated with Ganciclovir in different course, all alleviated the symptom and lesions in X-ray. Only one case had reversible neutropenia during treat. Conclusion CMV pneumonia in immunocompetent infants had long course of cough, probably accompany with wheezing and tachypnea and might had damage in other systems. The X-ray showing could be consolidation or interstitial lesions. The Ganciclovir is safe and effective for CMV pneumonia.