目的 探究甲硝唑(Met)联合雌三醇软膏治疗老年性阴道炎(SV)的效果及对患者生活质量的影响。方法 选取我院124 例SV患者为研究对象，采用随机数字表法分为Met组(对照组，n=62)和雌三醇软膏联合组(观察组，n=62)。对照组 给予Met治疗，观察组在此基础上给予雌三醇软膏治疗。比较两组症状(外阴瘙痒、阴道黏膜充血、阴道分泌物) 缓解时间和治疗前与治疗5周后阴道酸碱度(pH)、阴道健康评分、生活质量[欧洲五维健康量表(EQ-5D)]差异。结 果 观察组相关症状缓解时间均较对照组短(P＜0.05)。治疗5周后，两组阴道pH及各领域EQ-5D评分较治疗前下降(P ＜0.05)，阴道健康评分则升高(P＜0.05)，且观察组变化幅度大于对照组(P＜0.05)。结论 Met联合雌三醇软膏对 SV治疗效果较好且见效较快，且能调节患者内环境，提高其生活质量，对患者预后有利。

Objective To explore the effect of metronidazole (Met) combined with estriol ointment on senile vaginitis (SV) and its influence on patients' quality of life. Methods 124 SV patients in our hospital were taken as the research objects, and they were randomly divided into Met group (control group, n=62) and combination group of estriol ointment (observation group, n=62). Both groups were given Met, besides the observation group was given additional estriol ointment. The remission time of symptoms (vulva pruritus, congestion of vaginal mucosa and vaginal secretions) and the differences of vaginal pH values (pH), vaginal health scores and quality of life [European quality of life five dimension(EQ-5D)] before and 5 weeks after treatment in the two groups were compared. Results The remission time of related symptoms in the observation group was shorter than that in the control group (P<0.05). 5 weeks after treatment, the vaginal pH values and EQ-5D scores in the two groups were significantly decreased (P<0.05), the vaginal health scores in the two groups were significantly increased (P<0.05), and the change ranges in the observation group were greater than those in the control group (P<0.05). Conclusion Met combined with estriol ointment which has better and faster effect on SV, can regulate the internal environment of patients and improve their quality of life, and it is also beneficial to the prognosis of patients.