简体中文

论著-头颈部

拜阿司匹林联合吡格雷双抗对短暂性脑缺血发作的疗效

作者:林美容 麦汝娟 李世博

所属单位:广东省江门市开平市中心医院 (广东 江门 529300)

PDF

摘要

目的 探讨对短暂性脑缺血发作患者联合使用拜阿司匹林、氯吡格雷双抗治疗的效果。方法 依据治疗方案,将我院 2016年8月至2017年8月就诊的78例短暂性脑缺血发作患者分为2组,39例单独以拜阿司匹林展开治疗为单抗组,39 例以拜阿司匹林联合氯吡格雷双抗展开治疗为双抗组,对照两组疗效。结果 单抗组30例显效,其中,23例无效, 显效率为68.4%;双抗组36例显效,其中,6例无效,显效率为92.4%;双抗组优于单抗组,P<0.05。结论 对于短 暂性脑缺血发作的治疗,拜阿司匹林联合氯吡格雷展双抗开治疗效果更为优越,可减少再病发风险。

Objective To investigate the combined use of aspirin in patients with transient ischemic attack, the effect of clopidogrel therapy. Methods double antibody therapy, 78 cases of transient cerebral ischemia in our hospital from 2016 to 2017 8 months 8 months of onset were divided into 2 groups, 39 cases with single aspirin expansion the treatment for 39 cases with monoclonal antibody group, aspirin and clopidogrel resistance start treatment for double double anti control group, the efficacy of the two groups. Results The monoclonal antibody group in 30 cases, among them, 23 cases were invalid, the effective rate was 68.4%. Double resistance group was 36 cases, among them, 6 cases had no effect, the effective rate was 92.4%. Double resistance group was better than that of P<0.05. monoclonal antibody group. Conclusion for the treatment of transient ischemic attack, aspirin combined with clopidogrel show double antibody treatment effect is superior to open, can reduce the disease risk.

【关键词】短暂性;脑缺血;拜阿司匹林;氯吡格雷

【中图分类号】R743.31

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2019.02.008

前言

患者发作短暂性脑缺血,将出现椎基底动脉与颈 动脉系统有关症状,眩晕、无力等。短暂性脑缺血发 作存在危险的独立因素,跌倒发作。4%~8%近期频繁 的短暂性脑缺血发作的患者会继发成完全性卒中。该 病严重影响患者的生活质量水平,需快速对患者进行 有效的治疗。对此病的治疗,主要方法拜阿司匹林, 氯吡格雷两种,比较常用。本次研究分78例患者为2 组,分别以两种治疗方法、单独以拜阿司匹林,以拜 阿司匹林联合氯吡格雷双抗展开治疗,现对两组治疗 过程。结果对照分析如下。