目的 探究不同免疫丙种球蛋白(IVIG)治疗方式对新生儿ABO溶血病患儿预后的影响。方法 将68例新生儿ABO溶血 病患儿随机分为大剂量组(A组，34例)和小剂量组(B组，34例)。A组患儿予以单次大剂量IVIG+常规治疗，B组患儿 予以两次小剂量IVIG+常规治疗。观察两组患儿治疗前后血清总胆红素(TBIL)水平变化情况，比较两组患儿治疗5d 后红细胞(RBC)、红细胞比容(HCT)、血红蛋白(Hb)水平，以及光照时间、住院时间。结果 治疗1、3、5d后，两组 患儿血清TBIL水平均较治疗前降低，且A组低于B组(P﹤0.05)。治疗5d后，A组患儿RBC、HCT、Hb水平均高于B组(P﹤ 0.05)。A组患儿光照时间、住院时间均短于B组(P﹤0.05)。结论 单次大剂量IVIG治疗ABO溶血病的效果好，能有效 改善患儿贫血症状，缩短光照时间和住院时间，于病情转归有利。

Objective To explore the effects of different intravenous immunoglobulin (IVIG) therapy on the prognosis of neonatal ABO hemolysis. Methods 68 children patients with ABO hemolysis were randomly divided into high-dose group (group A, 34 cases) and low-dose group (group B, 34 cases). Group A was given single high-dose IVIG+ routine treatment, and group B was given two-time low-dose IVIG+ routine treatment. The changes of serum total bilirubin (TBIL) level in the two groups were observed before and after treatment. The red blood cells (RBC), hematocrit (HCT), hemoglobin (Hb), and illumination time and hospital stay were compared between the two groups after 5 d of treatment. Results After 1, 3 and 5 d of treatment, the serum TBIL levels in the two groups were lower than those before treatment, and the level in group A was lower than that in group B (P<0.05). After 5 d of treatment, the levels of RBC, HCT and Hb in group A were higher than those in group B (P<0.05). The illumination time and hospital stay in group A were shorter than those in group B (P<0.05). Conclusion Single high-dose IVIG has good effects in the treatment of ABO hemolysis, and it can effectively improve the anemia symptoms of children patients, shorten the illumination time and hospital stay, and is beneficial to the outcome of disease.