目的 观察丹参多酚酸盐静脉注射治疗急性脑梗死(Acute Cerebral Infarction, ACI)患者临床疗效及对患者脑 血流动力学、氧化应激指标的影响。方法 选取我院收治的108例急性脑梗死患者作为研究对象，随机分为观察组 和对照组各54例。对照组给予常规治疗方法；观察组在对照组的基础上联用丹参多酚酸盐静脉注射均治疗2周。 比较两组治疗后脑血流动力学以[大脑前动脉(Anterior cerebral artery，ACA)，大脑中动脉(Middle cerebral artery，MCA)以及大脑后动脉(Posterior cerebral artery，PCA)]及氧化应激各项指标[氧化低密度脂蛋白 (Oxidized low density lipoprotein，OX-LDL)、丙二醛(Malondialdehyde，MDA)]变化，并观察治疗结束后临床 疗效[神经功能缺损程度评分(National Institute of Health stroke scale，NIHSS)减分率]。结果 治疗后，观 察组ACA、MCA、PCA较对照组降低明显(P＜0.05)；氧化应激指标OX-LDL、MDA浓度比对照组有显著降低(P＜0.05)。 治疗后，观察组NIHSS量表评分总有效率为88.89%，高于对照组患者治疗后总有效率64.82%。结论 丹参多酚酸盐静 脉注射治疗急性脑梗塞临床疗效显著，可以有效改善患者脑血流动力学和氧化应激状态。

Objective To observe the clinical efficacy of intravenous injection of salvianolate in the treatment of patients with acute cerebral infarction (ACI) and its effects on cerebral hemodynamics and oxidative stress indexes. Methods 108 patients with acute cerebral infarction admitted to our hospital were selected as subjects and were randomly divided into observation group and control group, with 54 cases in each group. Control group was given conventional treatment, and observation group was given intravenous injection of salvianolate on the basis of control group, and they were treated for 2 w. The cerebral hemodynamics [anterior cerebral artery (ACA), middle cerebral artery (MCA) and posterior cerebral artery (PCA)] and oxidative stress indexes [oxidized low density lipoprotein (OX-LDL), malondialdehyde (MDA)] were compared between the two groups after treatment. And the clinical efficacy [National Institute of Health Stroke Scale (NIHSS) reduction rate] was observed after the end of treatment. Results After treatment, the ACA, MCA and PCA in observation group were significantly lower than those in control group (P<0.05). The oxidative stress indexes OX-LDL and MDA were significantly lower than those in control group (P<0.05). After treatment, the total effective rate of NIHSS scale score in observation group was higher than that in control group (88.89% vs 64.82%). Conclusion Intravenous injection of salvianolate has significant clinical efficacy in the treatment of acute cerebral infarction, and it can effectively improve the cerebral hemodynamics and oxidative stress status.