目的 观察分析基底动脉尖综合征患者应用高压氧联合局部亚低温疗法对其疗效及预后的影响。方法 选择医院2016 年6月-2017年6月收治的基底动脉尖综合征患者80例，按照随机数表法分为观察组(40例)和对照组(40例)，两组均 接受基底动脉尖综合征的常规内科治疗，对照组采用局部亚低温疗法，观察组在对照组治疗基础上采用高压氧治 疗，两组均治疗2周，治疗后所有患者均接受6个月的随访。对比两组患者治疗前后体内一氧化氮合酶、兴奋性氨基 酸、中性粒细胞数、总有效率及预后情况。结果 治疗后，观察组体内一氧化氮合酶、兴奋性氨基酸及中性粒细胞 数及神经功能缺损评分均明显低于对照组(P＜0.05)；观察组患者总有效率显著高于对照组(P＜0.05)；观察组患者 预后情况明显优于对照组(P＜0.05)。结论 高压氧联合局部亚低温疗法对基底动脉尖综合征患者的康复及预后有明 显的改善作用。

Objective To observe and analyze the effects of hyperbaric oxygen combined with local mild hypothermia therapy on the efficacy and prognosis of patients with top of basilar artery syndrome. Methods 80 patients with top of basilar artery syndrome who were admitted to the hospital from June 2016 to June 2017 were selected and divided into observation group (40 cases) and control group (40 cases) according to the random number table method. The two groups were given conventional medical treatment of top of basilar artery syndrome, and control group was given local mild hypothermia therapy, and observation group was treated with hyperbaric oxygen on the basis of control group, and the two groups were treated for 2 w, and all patients were followed up for 6 months after treatment. The nitric oxide synthase, excitatory amino acid, neutrophil count, total effective rate and prognosis were compared between the two groups before and after treatment. Results After treatment, the nitric oxide synthase, excitatory amino acid, neutrophil count and neurological deficit score in observation group were significantly lower than those in control group (P<0.05). The total effective rate in observation group was significantly higher than that in control group. The prognosis in observation group was significantly better than that in control group (P<0.05). Conclusion Hyperbaric oxygen combined with local mild hypothermia therapy can significantly improve the rehabilitation and prognosis of patients with top of basilar artery syndrome.