目的 探究奥美拉唑和埃索美拉唑对上消化道出血疗效及安全性影响。方法 采用随机数字表法将96例上消化道出血 患者分为奥美拉唑组(A组，n=48)和埃索美拉唑组(B组，n=48)。A组患者予以常规治疗+奥美拉唑静滴，B组患者予 以常规治疗+埃索美拉唑静滴。比较两组患者疗效和不良反应，观察治疗前后红细胞压积(PCV)、血清尿素氮(BUN) 水平变化情况。结果 两组患者治疗总有效率比较，差异无统计学意义(P﹥0.05)；治疗5d后，两组患者PCV较治疗前 升高，血清BUN则较治疗前降低(P﹤0.05)，组间比较差异无统计学意义(P﹥0.05)；A组不良反应发生率(25.00%)高于 B组(8.33%)(P﹤0.05)。结论 奥美拉唑和埃索美拉唑治疗上消化道出血的疗效均较高，且无明显差异，但埃索美拉 唑不良反应少，安全性更高。

Objective To explore the effects of omeprazole and esomeprazole on the efficacy and safety of upper gastrointestinal bleeding. Methods 96 patients with upper gastrointestinal bleeding were divided into omeprazole group (group A, n=48) and esomeprazole group (group B, n=48) according to the random number table method. Group A was given routine treatment + intravenous infusion of omeprazole, and group B was given conventional treatment + intravenous infusion of esomeprazole. The efficacy and adverse reactions of the two groups were compared. The changes of packed cell volume (PCV) and serum urea nitrogen (BUN) were observed before and after treatment. Results There was no significant difference in the total effective rate of treatment between the two groups (P>0.05). After 5 d of treatment, the PCV in the two groups was higher than that before treatment, and the serum BUN was lower than that before treatment (P<0.05), and the difference was not statistically significant between-groups (P>0.05). The incidence rate of adverse reactions in group A was higher than that in group B (25.00% vs 8.33%) (P<0.05). Conclusion Omeprazole and esomeprazole both have high efficacy in the treatment of upper gastrointestinal bleeding, and there is no significant difference, but esomeprazole has fewer adverse reactions and higher safety.