目的 探讨综合护理干预控制重症监护病房院内感染发生率的效果。方法 选取重症监护病房治疗的患者230例，随 机分成观察组及对照组(各115例)，对照组患者给予常规护理干预，观察组患者给予综合护理干预，观察分析两组 患者在院内感染发生情况。结果 观察组院内感染率低于对照组院内感染率(3.48% vs.16.52%)，差异有统计学意义 (P<0.05)；呼吸道、泌尿道、胃肠道是院内感染发生的主要部位。结论 综合护理干预在重症监护病房护理中的临 床效果显著，有效控制病房院内感染率，促进患者病情恢复，值得临床推广使用。

Objective To explore the effect of comprehensive nursing intervention on the incidence of nosocomial infection in intensive care unit. Methods A total of 230 patients in the intensive care unit were selected and randomly divided into control group and observation group (115 patients in each group). The patients in control group received routine nursing intervention, while patients in the observation group were given comprehensive nursing intervention, the incidence of nosocomial infection was compared between groups. Results The infection rate of the observation group was lower than that of control group (3.48% vs. 16.52%), the difference was statistically significant (P<0.05). The respiratory tract, urinary tract and gastrointestinal tract were the main sites of nosocomial infection. Conclusion The comprehensive clinical nursing effect in the intensive care unit has a significant clinical effect, effectively control the in-hospital infection rate of the ward and promote the recovery of the patient's condition, which is worthy of clinical promotion.