摘要
目的 探讨参附注射液对急性心肌梗死患者心功能的影响。方法 选取2016年3月-2017年3月在我院确诊为急性心肌 梗死患者58例,按随机数字法分为两组,29例患者给予常规治疗为常规组,29例患者给予常规治疗+参附注射液治 疗为探究组,观察两组疗效。结果 探究组的总有效率(79.31%)高于常规组(51.72%)(P<0.05);两组治疗后CI、 CO、LVEF指标均高于治疗前,HR指标低于治疗前,差异显著(P<0.05);探究组心功能各指标改善效果优于常规组 (P<0.05);两组治疗后TNF-α、CPR指标均低于治疗前,NO指标高于治疗前,差异显著(P<0.05);探究组TNF-α、 CPR及NO水平改善幅度显著于常规组(P<0.05);两组均未见明显不良反应。结论 参附注射液可有效改善急性心肌梗 死患者心功能,降低炎症反应,临床治疗安全有效。
Objective To explore the effects of Shenfu injection on cardiac function in patients with acute myocardial infarction. Methods 58 patients with acute myocardial infarction diagnosed in our hospital from March 2016 to March 2017 were selected and divided into two groups according to the random number table method. 29 cases given routine treatment were taken as routine group, and 29 cases treated with routine treatment + Shenfu injection were selected as study group. The efficacy of the two groups was observed. Results The total effective rate in study group was significantly higher than that in routine group (79.31% vs 51.72%) (P<0.05). After treatment, the indexes of CI, CO and LVEF in the two groups were higher than those before treatment while the index of HR was significantly lower than that before treatment (P<0.05). The improvements of cardiac function in study group were better than those in routine group (P<0.05). After treatment, the indexes of TNF-α and CPR in the two groups were lower than those before treatment while the index of NO was higher than that before treatment (P<0.05). The improvements of TNF-α, CPR and NO in study group were significantly better than those in routine group (P<0.05), and there were no obvious adverse reactions in the two groups. Conclusion Shenfu injection can effectively improve the cardiac function of patients with acute myocardial infarction and reduce the inflammatory responses, and its clinical treatment was safe and effective.
【关键词】参附注射液;急性心肌梗死;心功能
【中图分类号】R542.2+2
【文献标识码】A
【DOI】10.3969/j.issn.1009-3257.2018.06.005
前言
急 性 心 肌 梗 死 ( a c u t e m y o c a r d i a l infarction,AMI)与心室泵血功能减弱有关,患者具 有心肌缺血、缺氧、耗氧量急剧增加及冠状动脉痉挛 表现,可损害心肌细胞,诱发心律失常、心力衰竭 等症状[1]。我国AMI发病可高达45/10万~55/10万左 右,易导致左心室重构及心功能紊乱,出现心悸、胸 闷、气促、气短、疲倦乏力、憋喘难以平卧、浮肿尿 少等临床症状[2]。临床常应用西药治疗AMI,但多存 在禁忌症和毒副反应,不利于长期治疗,近年来临床 采用中药治疗AMI中,发现可明显改善患者心功能障碍,安全、有效,毒副反应小[3]。参附注射液作为纯 中药提取制剂,可有效AMI及AMI再灌注损伤后的心肌 细胞产生保护作用,常应用于心血管疾病、休克、心 律失常及心力衰竭等治疗中[6-7]。本文笔者研究参附 注射液辅助用于我院28例AMI患者治疗,探讨其疗效 及对患者心功能和炎症水平的影响,现报道如下。
罕少疾病杂志
第25卷, 第 6 期
2019年11月
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