目的 探讨2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)患者的代谢指标变化情况。方法 纳入我院收治的T2DM合 并NAFLD患者87例，作为研究组，同时选取同期收治的87例单纯T2DM患者作为对照组，观察两组代谢指标水平， 并分析T2DM并发NAFLD的危险因素。结果 ①研究组静息心率、收缩压、舒张压低于对照组，两组比较有差异性(P ＜0.05)；②与对照组相比，研究组UA、HbA1c、HCY、ALT、AST更高，HDL-C较低，组间对比差异显著；③T2DM合并 NAFLD危险因素包括TG、ALT与HCY。结论 T2DM合并NAFLD患者代谢水平有明显变化，HCY、ALT、TG水平增高对NAFLD 的发生有促进作用。

Objective To investigate the changes of metabolic indexes in patients with type-2 diabetes mellitus (T2DM) combined with nonalcoholic fatty liver disease (NAFLD). Methods 87 T2DM patients with NAFLD in our hospital were divided into study group, and at the same period another 87 pure T2DM patients were divided into control group. The metabolic indexes in the two groups were observed, and the risk factors of NAFLD combined with T2DM were analyzed. Results The resting heart rate, systolic and diastolic pressure in the study group were lower than those in the control group, and their differences were statistically significant (P<0.05). The UA, HbA1c, HCY, ALT and AST in the study group were higher than those in the control group, the HDL-C in the study group was lower than that in the control group, and their differences were statistically significant (P<0.05). The risk factors of T2DM combined with NAFLD were TG, ALT and HCY. Conclusion The changes of metabolic levels in patients with T2DM and NAFLD are significant, and the higher levels of HCY, ALT and TG, the higher occurrence of NAFLD.