目的 对比氨磺必利与利培酮治疗首发精神分裂症的临床疗效。方法 选取焦作市第四人民医院2016年3月至2017年3 月收治的60例首发精神分裂症作为研究对象，按照入院顺序，单号分为研究组(n=30)，双号作为对照组(n=30)，其 中对照组患者采用利培酮进行治疗，研究组患者采用氨磺必利药物进行治疗，对比两组患者的临床疗效，同时客观 评估两组患者治疗前后的阴性与阳性症状量表(PANSS)。结果 经比较，研究组和对照组患者的临床总有效率分别为 76.67％和66.66%，差异无统计学意义(P>0.05)；研究组患者治疗后2周、4周和8周的PANSS量表评分优于对照组和 治疗前，但P>0.05，不具有统计学意义。结论 氨磺必利与利培酮治疗首发精神分裂症的临床疗效相当，但是氨磺 必利对患者的阴性症状和抑郁症状的改善情况更好。

Objective To investigate the clinic effect of amisulpride and risperidone in treatment of first episode schizophrenic patients. Methods 60 cases with first episode schizophrenic in The Fourth People's Hospital of Jiaozuo from March 2016 to March 2017 were selected and divided into observation group (n=30) and control group (n=30), According to the admission order, the single number is divided into the study group (n=30), and the double number is the control group (n=30), clinic effect of the two groups was compared and PANSS of the two groups before and after treatment was objectively evaluated. Results After comparison, The total clinical efficiency of the study group and the control group was 76.67% and 66.66%, respectively, with no statistically significant difference (P>0.05). 2, 4 8 weeks after treatment, PANSS score of study group was better than control group and that before treatment,but P>0.05 was not statistically significant. Conclusion Amisulpride and risperidone has same clinic effect on treatment of first episode schizophrenic patients, but amisulpride can improve negative symptoms and depressive symptoms better.