目的 应用经颅多普勒超声(TCD)评价大脑前动脉发育不良患者的Willis环侧支循环效果。方法 选择31例大脑前动 脉(ACA)发育不良患者，以ACA发育不良侧及对侧粗大侧分为二组，检测发育不良侧组的大脑中动脉(MCA)，ACA血流 速度，并与粗大侧组比较；同时通过压迫同侧颈总动脉试验，应用TCD观察二组压迫后的MCA收缩峰血流速度(Vp)代 偿率，平均血流速度(Vm)代偿率及舒张末期血流速度(Vd)代偿率进行比较，二组分别与健康成人组相应各期代偿率 进行比较。结果 发育不良侧组的ACA血流速度显著低于粗大侧组(P<0.001)；发育不良侧组的MCA的Vp，Vm，Vd与粗 大侧组比较无显著性差异(P值分别为0.9072,0.7065,0.5676);压颈后发育不良侧组MCA的Vp，Vm，Vd代偿率分别为 (0.46±0.11),(0.50±0.11),(0.55±0.11)；粗大侧组代偿率分别为(0.43±0.14),(0.48±0.15),(0.53±0.17)， 两组比较无显著性差异(p值分别为0.3519，0.5517，0.5844)；健康正常组MCA的Vp，Vm，Vd代偿率分别为(0.47± 0.12),(0.52±0.13),(0.58±0.15)，患者中两组Vp，Vm，Vd代偿率分别与健康正常组比较也无显著性差异(P值分 别为0.6805，0.4405，0.3054及0.1224，0.1523，0.1193)。结论 TCD能实时评价ACA发育不良患者的颅内动脉侧支 代偿效果，患侧与健侧组代偿效果无显著性差异，且与正常健康成人的代偿效果无显著性差异。

Objective Application of transcranial Doppler ultrasound (TCD) in evaluation of collateral circulation in patients with anterior cerebral artery dysplasia (Willis). Methods 31 cases of anterior cerebral artery (ACA) in patients with ACA dysplasia, hypoplasia of ipsilateral and contralateral thick side were divided into two groups, artery dysplasia detection side of the brain (MCA), ACA blood flow velocity, and the bulky side. At the same time through the compression of the ipsilateral carotid artery were observed with TCD MCA test, the peak systolic velocity of two groups after pressure (Vp) compensation rate, mean flow velocity (Vm) compensation rate and the end diastolic velocity (Vd) were compared respectively with the compensatory rate, two healthy adults were compared with each group corresponding compensation rate. Results The blood flow velocity of ACA in the dysplastic group was significantly lower than that in the thick side group (P<0.001). There was no significant difference in MCA, Vm, Vd and Vp in the ipsilateral side group (P=0.9072,0.7065,0.5676). The adverse side group MCA development pressure neck after Vp, Vm, Vd compensation rates were (0.46±0.11), (0.50±0.11), (0.55±0.11), bulky side groups compensatory rate were (0.43±0.14), (0.48±0.15), (0.53±0.17), the two groups have no significant difference(P=0.3519, 0.5517, 0.5844). Healthy normal group MCA Vp, Vm Vd, compensatory rate were (0.47±0.12), (0.52±0.13), (0.58±0.15), two groups of Vp, Vm, Vd respectively compared with healthy normal compensatory group had no significant difference (P=0.6805, 0.4405, 0.3054 and 0.1224, 0.1523, 0.1193). Conclusion TCD can be used to evaluate the compensatory effect of intracranial arteries in patients with ACA dysplasia in real time, and there is no significant difference between the affected side and the contralateral side.