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左氧氟沙星联合痰热清注射液对社区获得性肺炎患者PSI、CURB-65评分的影响研究

作者:李诗文

所属单位:解放军第三七一医院急诊科 (河南 新乡 453000)

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摘要

目的 研究左氧氟沙星联合痰热清注射液对社区获得性肺炎(CAP)患者肺炎严重度指数(PSI)和CURB-65评分的影响。 方法 将2015年3月-2017年3月于我院接受治疗的198例CAP患者随机分为两组。联合组(100例)予以左氧氟沙星联合 痰热清注射液治疗;对照组(98例)予以左氧氟沙星注射液抗炎治疗。比较两组治疗前后病情严重程度指标(PSI、 CURB-65评分)评估结果及血清C反应蛋白(CRP)、血清降钙素原(PCT)检测结果差异。结果 治疗后,两组PSI评分、 CURB-65评分、CRP、PCT均较治疗前下降,且联合组明显低于对照组(P﹤0.05)。结论 左氧氟沙星联合痰清热注射液 可明显降改善CAP患者的病情严重程度,对调节其CRP、PCT水平、促进病情转归有利。

Objective To study the effect of Levofloxacin combined with Tanreqing injection on pneumonia severity index (PSI) and CURB-65 scores in patients with community acquired pneumonia (CAP). Methods 198 patients with CAP who received treatment in our hospital from March 2015 to March 2017 were randomly divided into two groups. The combined group (100 cases) was treated with Levofloxacin combined with Tanreqing injection, while the control group (98 cases) was given anti-inflammatory treatment with Levofloxacin injection . The evaluation results of severity indexes (PSI and CURB-65 scores) and the differences of serum C reactive protein (CRP) and serum procalcitonin (PCT) between the two groups were compared before and after treatment. Results After treatment, the scores of PSI and CURB-65, and levels of CRP and PCT in the two groups were decreased, and all these indexes in the combination group were significantly lower than those in the control group (P<0.05). Conclusion Levofloxacin combined with Tanreqing injection which is beneficial for regulating the levels of CRP and PCT and promoting the prognosis of disease, can obviously improve the severity of CAP patients.

【关键词】左氧氟沙星;痰热清注射液;社区获得性肺炎;PSI评分;CURB-65评分

【中图分类号】R563.1

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2018.05.013

前言

社区获得性肺炎(CAP)是一种由细菌、非典型病 原体及病毒感染所致的感染性肺实质炎症,以发热、 咳嗽、咳痰、胸痛及呼吸困难等临床表现为主[1],有 一定社会危害性,目前主要治疗手段为服用抗菌药 物。PSI、CURB-65评分与CAP患者的病情危重成正相 关,可用于评估CAP患者的病情严重程度。CRP是评价 感染的常用指标,PCT是特异性较高的炎症标记物, 两者均可评估CAP患者的病情严重程度及预后。近年 来,由于抗生素滥用导致肺炎链球菌等致病菌耐药性 增强,单独使用左氧氟沙星抗炎治疗CAP的效果不理 想,因此临床上常采用左氧氟沙星联合痰热清注射液治疗CAP。本研究旨在观察左氧氟沙星联合痰热清注 射液对CAP患者PSI、CURB-65评分的影响,以及对血 清中CRP、PCT的影响,以期为更多患者获得良好预后 提供依据,现报道如下。