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益母草注射液在产后缩宫止血效果的临床观察

作者:陈晓敏 景 艳 郭丽璇

所属单位:汕尾逸挥基金医院(汕尾市第二人民医院)妇产科 (广东 汕尾 516600)

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摘要

目的 观察评价益母草注射液在产后缩宫止血中的临床效果。方法 选择2015年7月-2017年6月期间我院收治的阴 道自然分娩产妇160例,随机对照试验(Randomized Controlled Trial,RCT)分为两组,对照组80例患者经阴道 自然分娩胎盘娩出后缩宫素(马鞍山丰原制药厂,H34020474)治疗;观察组80例在对照组基础上加益母草注射液 (成都第一制药有限公司,z51021448)治疗,并观察两组的出血量及临床效果。结果 观察组孕产妇产后2h、24h 出血量显著地低于对照组(分别t=34.8643、29.5728,P<0.05);观察组产后出血发生率为2.50%明显低于对照组 11.25%(χ2 =4.7834,P<0.05);两组孕产妇在用药后第2d、4d、6d后的宫底高度慢慢的缩短,而观察组孕产妇在 用药后第2d、4d、6d后的宫底高度均显著地短于对照组(分别t=3.1257、3.9013、4.0376,P<0.05)。结论 阴道自 然分娩产妇经益母草注射液联合缩宫素能够有效的预防产后出血,出血量少、出血率低,提高宫缩强度,对产妇产 后子宫恢复具有理想的效果,值得临床大力推广应用。

Objective To observe and evaluate the clinical effect of Leonurus injection in postpartum systolic and hemostasis. Methods A total of 160 natural vaginal delivery mothers were selected from July 2015 to June 2017 at ShanweiYihui Fund Hospital (Shanwei Second People’s Hospital). The Randomized Controlled Trials (RCT) were divided into two groups. Eighty patients in the group were treated with vaginal delivery of oxytocin after delivery of the placenta; 80 patients in the observation group were treated with Motherwort injection on the basis of the control group, and the bleeding volume and clinical efficacy of the two groups were observed. Results The amount of bleeding at 2h and 24h postpartum in the observation group was significantly lower than that in the control group (t=34.8643, 29.5728, P<0.05, respectively), the incidence of postpartum hemorrhage in the observation group was significantly lower than that in the control group (11.25%) (χ2 =4.7834, P<0.05). The height of the uterus at the 2nd, 4th, and 6th days after maternal use was gradually shortened in the two groups, while the height of the uterine fundus in the observation group was 2d, 4d, and 6d after the administration. Significantly shorter than the control group (t=3.1257, 3.9013, 4.0376, respectively, P<0.05). Conclusion The vaginal delivery of natural maternal motherwort injection combined with oxytocin can effectively prevent postpartum hemorrhage, less bleeding, low bleeding rate, increase the intensity of contractions, and has an ideal effect on maternal postpartum uterine recovery. It is worthy of clinical application.

【关键词】孕产妇;益母草注射液;缩宫素;止血效果

【中图分类号】R271.43

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2018.04.015

前言

孕产妇产后出血(Postpartum hemorrhage,PH) 是指胎儿娩出后24h内出血量阴道分娩时超过500 mL,是产妇分娩期严重并发症,且发病率一直处于上 升态势,产后出血(PH)首要原因还是子宫收缩乏力, 出血速度快、出血量大,极有可能会引起产妇休克死 亡,一直是我国产妇死亡的最常见原因之一,所以在 产妇分娩娩过程中应严密监测出血情况[1-3]。产后出 血已经成为我国大部分地区孕产妇死亡的第一位原因。随着我国对二孩政策全面放开,高龄及高危孕产 妇而显著地增多,给控制孕产妇死亡带来压力[4]。缩 宫素属于神经垂体类多肽物质,其半衰期较短,近年 来产科在临床上用于促进子宫收缩的常用药物[5]。益 母草其半衰期为6h,药效维持时间较长,能够加强孕 产妇子宫收缩,具有抗凝、溶栓、降脂、改善微循 环、抑制血小板聚集等作用[6-7]。本研究运用益母草 注射液联合缩宫素预防经阴道自然分娩产妇产后出血80例,取得满意的效果,现将结果总结分析报道如 下。