目的 研究炎性因子、血脂肪水平和脂肪酸(fatty acid FA)组成与活动期溃疡性结肠炎(Ulcerative Colitis, UC) 和克隆恩氏病(Crohn’s disease, CD)的相关性。方法 对28例UC和30例CD患者的饮食、Harvey-Bradshaw 活动指 数 (HBAI)、炎性因子、脂蛋白和脂肪酸组成进行记录和分析。结果 两组间患者的临床资料无统计学差异。两组患 者血浆总胆固醇水平与肠蠕动频率成反比。CD患者血浆总脂蛋白和HDL与CRP成反比，而UC患者HDL与CRP成反比。UC 和CD患者中CRP、IL-6与饱和FA均具有相关性；另CRP与n-6 MUPF和HDL具有正相关性，而与n-3 MUPF呈负性相关。 结论 UC和CD患者发生脂蛋白、脂肪酸等代谢变化，均与全身性炎症状态相关，与饮食的摄入和胃肠道的运动无 关。

Objective To evaluate the relationships between infammatory parameters, plasma lipids and phospholipid fatty acid (FA) composition in patients with active UC and CD. Methods Diet, the Harvey-Bradshaw Activity Index (HBAI), inammatory parameters, lipoproteins and FA composition were assessed in 28 UC and 30 CD. Results No differences in clinical parameters were observed in the two groups. Total cholesterol correlated inversely with the number of bowel movements in both groups. Total and HDL cholesterol were inversely related to C-reactive protein (CRP) in CD while HDL correlated with CRP in UC. CRP and IL-6 were related to Saturated FA in the both group, in addition, CRP correlated positive with n-6 MUPFand HDL but inversely with n-3 MUPF. Conclusion Lipoproteins and FA composition were varied in active inflammatory bowel diseases and were correlated with the systemic inflammatory status, but was unrelated to dietary intake and intestinal disease activity.