目的 探究血管紧张素Ⅱ、醛固酮水平与原发性高血压的关系。方法 选取我院2015年4月-2017年4月期间收治的 150例原发性高血压患者为研究对象，按照原发性高血压分级标准将其分为1级组(n=45)、2级组(n=50)和3级组 (n=55)，同时选取同期在本院体检正常者(n=40)为对照组研究对象，比较各组研究对象血管紧张素Ⅱ和醛固酮水 平，采用Pearson相关性分析血管紧张素Ⅱ、醛固酮水平与原发性高血压的关系。结果 3组高血压患者血管紧张素 Ⅱ和醛固酮水平显著高于对照组，3级组血管紧张素Ⅱ和醛固酮水平显著高于1级组和2级组，2级组血管紧张素Ⅱ和 醛固酮水平显著高于1级组，差异具有统计学意义(P<0.05)；Pearson相关性分析结果显示，原发性高血压与血管紧 张素Ⅱ(r=0.901,P<0.05)和醛固酮水平(r=0.833,P<0.05)正相关。结论 血管紧张素Ⅱ、醛固酮水平与原发性高血 压密切相关。

Objective To investigate the relationship between the levels of angiotensin II and aldosterone levels and primary hypertension. Methods From Apr. 2015 to Apr. 2017, 150 patients with primary hypertension in our hospital were taken as the research objects, and they were divided into grade-1 group (n=45), grade-2 group (n=50) and grade-3 group (n=55) according to the classification standard of primary hypertension. At the same time, the subjects who had normal physical examination in our hospital (n=40) were selected as the control group. The levels of angiotensin II and aldosterone in each group were compared, and the relationship between the levels angiotensin II and aldosterone and primary hypertension was analyzed by Pearson correlation analysis. Results The levels of angiotensin II and aldosterone in the three groups with primary hypertension were significantly higher than those in the control group, the levels of angiotensin II and aldosterone in the grade-3 group were significantly higher than those in Grade-1 group and Grade-2 group, the levels of angiotensin II and aldosterone in the grade-2 group were significantly higher than those in the grade-1 group, their differences were statistically significant (P<0.05). Pearson correlation analysis showed that primary hypertension was positively related to angiotensin II (r=0.901, P<0.05) and aldosterone levels (r=0.833, P<0.05). Conclusion Angiotensin II and aldosterone levels are closely related to primary hypertension.