目的 观察奥司他韦联合炎琥宁治疗小儿病毒性肺炎（children with virus pneumonia, CVP）的疗效及安全性。 方法 将890例CVP患儿随机分为观察组（452例）和对照组（438例）。观察组患儿予以奥司他韦联合炎琥宁治疗， 对照组患儿予以炎琥宁抗病毒治疗。观察两组患儿临床疗效、主要症状及体征消失时间的差异，记录其不良反应发 生率。结果 观察组总有效率明显高于对照组（P﹤0.05）；主要临床症状及体征（发热、咳嗽、气促及肺湿罗音） 消失时间则明显短于对照组（P均﹤0.05）。两组患儿不良反应发生率无统计学意义（P﹥0.05）。结论 奥司他韦联 合炎琥宁疗法对改善CVP临床疗效、缩短患儿相关症状缓解时间等有利，且不良反应发生少。

Objective To observe the curative effect and safety of Oseltamivir combined with Yanhuning on children with virus pneumonia (CVP). Methods 890 children with CVP were randomly divided into observation group (452 cases) and control group (438 cases). The observation group was treated with oseltamivir combined with Yanhuning, while the control group was given Yanhuning antiviral therapy. The differences of clinical efficacy, main symptoms and signs disappearance time between the two groups were observed, and the incidence of adverse reactions was recorded. Results The total effective rate in the observation group was significantly higher than that in the control group (P<0.05), the disappearance time of main clinical symptoms and signs (fever, cough, shortness of breath and rales) in the observation group was significantly shorter than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Oseltamivir combined with Yanhuning therapy which has less adverse reactions, can not only improve clinical curative effect of children with CVP, but also shorten their remission time of related symptoms.