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肝脏局灶性结节增生的影像学特点及介入治疗(附5例报告并文献复习)

作者:邓海辉 招伟成 陈 斌 谢宗贵 王晓萍 林 敏

所属单位:深圳市中医院介入科 (广东 深圳 518033)

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摘要

目的 探讨肝局灶性结节增生(focal nodular hyperplasia,FNH)的CT、DSA表现及超选择性肝动脉分支栓塞术的 治疗效果。方法 5例CT扫描初步诊断为FNH的病人、行肝动脉DSA观察肝内结节灶的动脉血供情况,随后采用平阳霉 素-碘化油乳剂加PVA颗粒行结节灶供血肝动脉分支超选择插管栓塞。栓塞完毕即在DSA电视透视下对含有碘油药物 乳剂的结节灶行经皮穿刺活检术。结果 FNH的CT表现:平扫肝内结节灶为低密度,动脉期明显强化,结节中心见 无强化的瘢痕。门脉期、延迟期病灶强化减退,与肝脏成等密度。肝动脉DSA:动脉期结节病灶血供丰富,可见供 血动脉进入病灶后血管分支呈放射状向周围分布,病灶周围肝动脉分支可呈抱球状。DSA门静脉期和实质期均见病 灶内造影剂染色不均,可见无染色的放射状分隔,但病灶边界清楚。5例中肝动脉DSA 4例见结节灶-肝静脉分支引 流,1例见结节灶-门脉分支引流。5例均成功施行结节灶肝动脉供血分支栓塞和穿刺活检术。术后CT随访1-3年,2 例病灶消失,2例明显缩小,1例无变化,残留结节灶无强化。结论 对FNH定性诊断,CT增强、肝动脉DSA有一定的 特征性,最终诊断仍需依赖病理结果。经肝动脉超选择性栓塞治疗FNH是一种安全、微创、有效的方法。

Objective To evaluate the features of computed tomography (CT) and hepatic artery digital subtraction angiography (DSA) of hepatic focal nodular hyperplasia (FNH), and the therapeutic effects of super selected transarterial embolization for the treatment of FNH. Methods Five consecutive patients with primary diagnosed as hepatic FNH by CT scan were underwent hepatic artery DSA and super selected transarterial embolization using bleomyciniodinated oil and polyvinyl alcohol particles. At same time, live lesions puncture biopsy were done immediately after embolization guided by fluoroscopy. Results CT features of hepatic FNH in 5 patients lined below: Pre-contrast CT scanning showed hypodense lesions and showed progressive enhancement in most part of lesions except centre scar in the artery phase, but isodense in the portal and equilibrium phases in contrast-enhanced CT scanning. Hepatic artery DSA showed plentiful blood supplying for FNH lesions. Hepatic artery branches ranked like a wheel in lesions and like ball-griping around the lesions. In portal vein and parenchymal phase of CT scanning, contrast sinking was not well-distributed in lesions and some dividing strip without contrast sinking in lesions could be seen. All lesions have clear margins. Abnormal lesions-branches of hepatic vein draining in 4 lesions and lesion-branch of port vein draining in 1 lesion were found. All 5 patients underwent super selected embolization of supplying artery branches and lesions biopsy. In the follow-up 12-36 months period, 2 lesions had complete resolution. 2 lesions had significantly reduced volume, but 1 lesion had no changed. Contrast-enhanced scanning at follow-up showed completely lacking of arterial blood supply in the residual lesions. Conclusion CT scanning and hepatic artery DSA can provide some characteristics for diagnosis of FNH lesions, but confirmed diagnosis need biopsy results. Super selected transarterial embolization is a safe, micro invasive and effective method for treatment of hepatic FNH.

【关键词】肝脏局灶性结节性增生;影像学;动脉栓塞术;活检

【中图分类号】R445.3

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2018.03.015

前言

FNH是一种较少见的肝细胞源性良性肿瘤,由于 肝脏的许多病变表现为结节状,故在临床中可能会将 FNH误认为其他肝脏结节状病变。本文回顾5例经病理证实为FNH的CT、DSA表现及超选择性肝动脉栓塞治疗 效果,旨在加深对该病诊疗的认识。