目的 研究溃疡性结肠炎患者血清miRNA21的水平，并探讨其在溃疡性结肠炎发展中的意义。方法 选取溃疡性结肠 炎患者25例及正常对照组20例，采用qRT-PCR方法检测血清miRNA21的水平。结果 溃疡性结肠患者血清miRNA21的水 平为1.32±0.24，正常对照组血清miRNA21的水平为1.11±0.17。溃疡性结肠组有轻度升高，且差异有统计学意义 (P＜0.05)。结论 溃疡性结肠炎患者血清miRNA21的表达上调，可能为溃疡性结肠炎的治疗及临床诊断提供新的方 向。

Objective Analysis of miRNA21 in the patients with ulcerative colitis to investigate the pathogenesis of ulcerative colitis. Methods 25 patients with ulcerative colitis and 20 healthy controls were detected. And the expression of miRNA21 was evaluated by using quantitative real-time polymerase chain reaction (QRT-PCR) analysis. Results miRNA21 in serum of patients with ulcerative colitis was 1.32±0.24, higher than that 1.11±0.17 of the healthy control group, the difference had statistical significance (P<0.05). Conclusion The up-regulated expression of miRNA21 in the patients with ulcerative colitis might provide a new direction of therapy and clinical diagnosis for ulcerative colitis.