目的 探讨在已明确诊断2型糖尿病的患者中，成人隐匿性自身免疫性糖尿病在其中所占的百分比。方法 对已明确 诊断的2型糖尿病178例,依据BMI进行分组，按成人隐匿性自身免疫性糖尿病诊断标准，检测空腹C肽、谷氨酸脱羧 酶抗体(GAD65)、胰岛细胞自身抗体(ICAs)。结果 在已明确诊断的2型糖尿病178例患者中，检测出成人隐匿性自 身免疫性糖尿病共13例，其中消瘦组和正常组分别占5.62%(10/178)，1.65%(3/178)，而超重和肥胖组为0%，合计 7.31%，这一比率较明显低于有效控制糖尿病全球合作组织(GPEDM)发布的10%，高于国内相关报道患病率6.0%。结 论 临床医生要警惕成人隐匿性自身免疫性糖尿病这一亚型在2型糖尿病中的存在。

Objective To investigate the proportion of latent autoimmune diabetes in adult (LADA) in patients with type 2 diabetes mellitus. Methods A total of 178 patients with type 2 diabetes mellitus were classified by body mass index (BMI) levels. Fasting plasma C-peptide, glutamic acid decarboxylase antibody (GAD65), and islet cell autoantibody (ICAs) were detected. Results The proportion of LADA in patients with type 2 diabetes mellitus of angular group and normal group were 5.62%(10/178),1.65%(3/178)respectively.No patient was LADA in overweight or obese group. The total proportion of LADA in the present study was 7.31%, which was significantly lower than the proportion (10.0%) reported by Global Partnership for Effective Diabetes Management but higher than the proportion of 6.0% reported by several studies in China. Conclusion LADA in patients with type 2 diabetes mellitus should be taken into account in clinical practice.